The Sikeston Depot – Cultural Center & Museum
116 West Malone, Sikeston (Malone Avenue and North New Madrid Street; Downtown Sikeston)
Telephone: 573-481-9967
Hours of Operation: Tuesday- Saturday 10 a.m.- 4 p.m.; Sunday 1 p.m.- 4 p.m.
Admission: Free
Description: Visitors seeking to feel the heritage and experience the culture of the Sikeston area will enjoy a tour of The Sikeston Depot Museum, the region’s newest historic museum and cultural arts center. Housed in the city’s historically renovated train depot on one of the first rail lines constructed west of the Mississippi, the depot features a historic museum recounting the most important aspects of the area’s culture; an art gallery in which local artists display their work; and a cultural center displaying traveling exhibits from national museums.
Website: www.sikestondepotmuseum.com
Downtown Sikeston Historic Homes Driving Tour (top of page)
In the early 1900's Sikeston boasted more millionaires per capita than any other city of its size in the United States. Enjoy a driving tour of more than 24 of the magnificant homes constructed during that period. Brochures available from the Sikeston CVB, #1 Industrial Drive, Sikeston (573-471-6263) or at the Sikeston Depot Cultural Center and Museum, Malone Avenue at North New Madrid (573-481-9967).
Sikeston Public Library (top of page)
121 East North Street, Sikeston
Telephone: 573-471-4140
Hours of Operation: Monday-Thursday 10 a.m.- 8 p.m.
Friday 10 a.m.- 6 p.m.;Saturday 10 a.m.- 4 p.m.; & Sunday 1 p.m.- 5 p.m.
(Open Sundays during school year only)
Admission: Free
Description: The Sikeston Public Library features a collection of genealogy records focusing on southern Scott County, Missouri,
and the library offers special programs throughout the year.
Website: www.sikeston.lib.mo.us
Southeast Missouri Agriculture Museum (top of page)
County Road 532 East, Sikeston
Telephone: 573-471-3945
Hours of Operation: Monday- Saturday 9 a.m.- 4 p.m.; Sunday 1 p.m.- 4 p.m.
Admission: $3
Description: Boasting the largest collection of antique farm machinery in Missouri, this museum showcases the region’s rich agriculture heritage through the display of 6,000 plus pieces of antique farm equipment. The indoor display areas include the main museum and five outer buildings of great historic interest, including two Missouri log cabins (circa 1880), one wooden railroad caboose, one relocated railroad depot, and a reconstructed 1920’s service station. 
Agricultural Murals (top of page)
Cotton Planting - 102 North Kingshighway, Downtown Sikeston
Cotton Country - US Bank (Lobby), Front Street at North New Madrid Street, Downtown Sikeston
History of Sikeston -127 West Center Street, Exterior of Craftmasters Building
El Camino Real Historic Marker (top of page)
North Kingshighway at Woodlawn Avenue, Downtown Sikeston
Throughout history the Sikeston area has belonged to three different nations: France, Spain and the United States. In 1789, while under the Spanish rule, the King of Spain ordered the designation of an overland route to connect the cities of St. Louis and New Orleans. This route, superimposed over an old Indian and buffalo trail, was the most important north-south route in the Mississippi Valley. It was along this early frontieer route, known as the El Camino Real or King's Highway, that the City of Sikeston was founded in 1860. This marker was erected by The Missouri Daughters of the American Revolution in 1915.
Veterans Park (Harvey Parks Air Base) (top of page)
Malone Avenue at Linn Street, Sikeston
Anticipating World War II, General Hap Arnold planned the Harvey Parks Air Base of Sikeston. The base, which was activated in 1940, served as a flight training school for pilots entering the U.S. Army Air Corps. One of only five civilian bases in the nation, the base is now the SIkeston Municipal Airport. The original gated entrance to Harvey Parks Air Base now serves as the entrance to Sikeston's Veterans Park. A brick walkway leads to a large monument in the center of the park, inscribed with the names of veterans from the Sikeston area. Other features of the park include displays from all branches of the miltary.
Stars & Stripes Museum, Bloomfield (top of page)
Website: http://www.starsandstripesmuseumlibrary.org/index.php
Telephone: 573-568-2055
Hunter Dawson Historic Site, New Madrid (top of page)
Website: http://www.mostateparks.com/hunterdawson.htm
Telephone: 573-748-5340 